Principal Scientist – Team Lead

Intonation Research Laboratories is accelerating drug discovery and creating better therapeutics by supporting its clients in chemical synthesis, biochemical and cell-based assays, etc. We have assembled a diverse team with extensive experience across drug discovery disciplines. This continuum of complementary skills is essential for driving our scientific vision and needs to support our clients. We science inspired, perseverant, synergistic, supportive, intrepid, and inclusive company. If you are inspired to bring better medicines to patients within a collaborative organization, then Intonation could be the right place for you.

• Design, execute, and independently run biochemical and biology experiments
• Critically analyze, interpret, and present data to the team
• Collaborate with senior researchers) to develop, optimize, validate, and automate biochemical and cellular assays to characterize small molecules inhibitors for hit-finding, hit-to-lead, and lead-optimization
• Communicate ideas and results to internal and external parties in verbal, written, and presentation formats
• Establish cellular models of disease an
• d execute assays to evaluate drug activity and mechanism of action

• PhD in biology or related fields, with an emphasis on biochemistry, cell biology, and molecular biology with min 8+ years of experience.
• Demonstrated experience with biochemical and cell culture assays development, validation and miniaturisation for primary screen utilising different technologies (ex: SPA, HTRF, Alpha screen, Nano BRET, LANCE)
• Laboratory techniques such as ELISA, western blots, immunofluorescence, qPCR, and gene expression
• To perform enzymatic assays and MOA studies (mechanism of action) for lead compounds
• Understanding of Enzymology including enzyme kinetics.
• Strong ability to analyze and communicate complex data in a clear and concise manner
• Team player with excellent interpersonal skills and attention to detail